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Did you know a study in Greyhounds found that giving amantadine twice a day works better for chronic pain in dogs? This shows how effective this drug can be for dogs with pain from osteoarthritis. Amantadine is a key drug for managing chronic pain in dogs. It works by blocking NMDA receptors in the nervous system. This helps stop and even reverse the increased pain sensitivity dogs can get over time. Vets often use it with other pain meds like NSAIDs or gabapentin for better pain control in dogs with ongoing conditions.